All hematologic malignancies blood cancers specific storage diseases, metastatic tumors involving bones all can be diagnosed by 1: Bone marrow Aspiration 2 – Bone marrow Trephine biopsy.  

Bone marrow aspiration and bone marrow biopsy are procedures to collect and examine bone marrow — the spongy tissue inside some of your larger bones. Bone marrow aspiration and bone marrow biopsy can show whether your bone marrow is healthy and making normal amounts of blood cells. Doctors use these procedures to diagnose and monitor blood and marrow diseases, including some cancers, as well as fevers of unknown origin.